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Gastrointestinal stromal tumor

1 OMIM reference -
5 associated genes
18 signs/symptoms

PROTEIN INTERACTIONS: 1

Legius syndrome

1 OMIM reference -
1 associated gene
No signs/symptoms info

Gastrointestinal stromal tumor

Legius syndrome

KIT	(UniProt - OMIM)		SPRED1	(UniProt - OMIM)
PDGFRA	(UniProt - OMIM)
SDHA	(UniProt - OMIM)
SDHB	(UniProt - OMIM)
SDHC	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	KIT	(0.59)	SPRED1

Citations in the biomedical literature:

Gastrointestinal stromal tumor		Legius syndrome
	Synonym(s): - GIST		Synonym(s): - NF1-like syndrome - Neurofibromatosis 1-like syndrome

	Classification (Orphanet): - Rare gastroenterologic disease - Rare genetic disease - Rare oncologic disease		Classification (Orphanet): - Rare developmental defect during embryogenesis - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: adulthood Average age of death: - Type of inheritance: sporadic		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: - Average age of death: - Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - 1 MeSH reference: D046152		External references: 1 OMIM reference - 1 MeSH reference: C548032

Gastrointestinal stromal tumor
	Very frequent - Estomach / gastric neoplasm / tumor / carcinoma / cancer - Sarcoma Frequent - Asthenia / fatigue / weakness - Constipation - Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia - Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia - Intestinal obstruction / ileus - Intestinal perforation - Nausea / vomiting / regurgitation / merycism / hyperemesis Occasional - Anaemia - Colon neoplasm / tumor / carcinoma / cancer - Cutaneous rash - Digestive neoplasm / tumor / carcinoma / cancer - Esophageal neoplasm / tumor / carcinoma / cancer - Hepatitis / icterus / cholestasis - Irregular / in bands / reticular skin hyperpigmentation - Rectum / rectal neoplasm / tumor / carcinoma / cancer - Small bowel neoplasm / tumor / carcinoma / cancer
Legius syndrome
(no data available)